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Which enzyme activates glycogen synthesis?

  1. Glycogen degrase

  2. Glycogen phosphorylase

  3. Glycogen synthase

  4. Insulin

The correct answer is: Glycogen synthase

Glycogen synthase is the enzyme responsible for activating glycogen synthesis. It catalyzes the addition of glucose units to the growing glycogen chain, helping to convert glucose into glycogen for storage in the liver and muscles. The regulation of glycogen synthase is crucial during times of energy surplus, such as after a meal when glucose levels are elevated. This enzyme's activity is stimulated by dephosphorylation and can be influenced by various hormones, particularly insulin. When insulin is released in response to increased blood sugar levels, it activates glycogen synthase, promoting the storage of excess glucose in glycogen form. Understanding the role of glycogen synthase is essential in the study of metabolism and energy storage, as it plays a central role in maintaining blood glucose levels and ensuring that glucose is available for energy when needed.